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  1. Hello Mr. McMullin, Thank you for your service, your time, your business, and of course for this amazing review! I have just created and moved your topic into our new Heartland CBD reviews. We also have added a review button to our homepage as well that takes you over to Google :) Thank you again, and we look forward to seeing you again soon!
  2. This topic has been created for others to respond too! We can now all talk without losing place of what was said.
  3. Recently in the news, I have seen many stories about how hemp CBD isn't always consistent with the labeling. This is growing in number!
  4. NEWSLETTER MAY 24. 2019 May 24, 2019 Introduction: We at Heartland Hemp Inc. want to spread the science behind the CBD explosion, and the importance of the Endocannabinoid System (ECS). So here are a few selections regarding the ECS from www.verywellhealth.com and What Is the Endocannabinoid System? by Adrienne Dellwo published and medically reviewed in April 2019. “To understand the ECS, it first helps to understand what homeostasis is. Basically, homeostasis is your body’s efforts to keep everything in the right zone. It tries to keep your internal environment stable and optimal no matter what’s going on in the environment around you. Think of all the gauges in the dashboard of a car or airplane. Those all tell the operator whether things are—or aren’t—operating in the proper zone. Just like the electronics in a car or plane, your body works continuously to monitor important levels and functions in your body. Is your temperature too high, too low, or just right? Are your hormone levels what they should be? Is your heart beating too fast? Do you need fuel or rest? Is too much of something building up in your bloodstream or inside of your cells? When something is operating outside of the right range, your body activates the ECS to help correct it. So when you’re really hot and begin to sweat, thank your ECS for working to cool you down. Stomach growling? That’s your ECS helping remind you to eat because you need fuel. The ECS does this via cannabinoid receptors found in select tissues. We have (at least) two types of cannabinoid receptors: · CB1 which is in the central nervous system (brain and nerves of the spinal cord) · CB2 which is in the peripheral nervous system (nerves in your extremities), the digestive system, and specialized cells in the immune system Cannabinoid receptors are believed to be among the most plentiful in our central nervous system, and some researchers hypothesize that we could have a third, undiscovered one, as well. Through those receptors, the ECS helps regulate a lot of important functions, such as: · Appetite · Mood · Memory · Digestion · Sleep · Motor control · Immune function · Pain · Reproduction/fertility · Inflammation, including neuroinflammation · Pleasure/reward · Temperature regulation Your body activates the ECS with precision so that it impacts only what it needs to. For example, if your reproductive hormones are out of whack, it will work to regulate them without altering your digestion or immune system. Then, once the endocannabinoids have done their job and brought things into balance, certain enzymes come along to break them down and prevent them from going too far and upsetting the balance in the opposite direction. It’s a precise response. That’s different from what happens if someone smokes marijuana and floods their system with cannabinoids. Then the drug has wide-ranging impacts on physiology, some of which may be beneficial while others may be harmful. Homeostasis is essential to our health and survival, so when the ECS isn’t working properly, it can cause a lot of problems for you.” “As medical science has learned more about the ECS, it’s also discovered several conditions that appear to be related to dysregulation of the system, which is called clinical endocannabinoid deficiency (CECD). CECD isn’t a disease itself but is an umbrella term encompassing conditions with this common feature. The CECD conditions include: Fibromyalgia, Migraine, Irritable bowel syndrome These conditions are sometimes called “functional conditions” or “central sensitivity syndromes.” They tend to be resistant to most treatments, so researchers are looking into cannabis-based treatments. These conditions also generally involve more than one system—which makes sense when you look at the areas influenced by the ECS. For example, fibromyalgia involves the central and peripheral nervous systems, the immune system, the endocrine (hormonal) system, and even the digestive system. It’s also been linked to premature perimenopause, problems with conception, and early hysterectomy. Temperature sensitivity and poor memory are common symptoms. That seems like a grab-bag of unrelated problems until you think about homeostasis and the ECS. We’re still early in the process of figuring out how to correct endocannabinoid deficiency, but the increasing availability of medical marijuana and CBD products has been largely embraced by the patient community and we’re likely to see a lot more research in that area.” (https://www.verywellhealth.com/what-is-the-endocannabinoid-system-4171855 ) By now, most people have heard about cannabinoids such as Delta-9 THC and CBD. While these compounds have a range of medical benefits, they are only part of what makes cannabis therapy so effective; and have proven to be less effective on their own than when combined with other phytochemicals like terpenes. Both cannabinoids and terpenes affect receptors in the endocannabinoid system which is what allows cannabis to act therapeutically in the human body. “The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB1 receptors) and in the periphery (primarily but not exclusively CB2 receptors) are only partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids (phytocannabinoids) and chemically related compounds, like the terpenes, commonly found in many foods, have been found to exert significant analgesic effects in various chronic pain conditions. Currently, the use of Δ9-tetrahydrocannabinol is limited by its psychoactive effects and predominant delivery route (smoking), as well as regulatory or legal constraints. However, other phytocannabinoids in combination, especially cannabidiol and β-caryophyllene, delivered by the oral route appear to be promising candidates for the treatment of chronic pain due to their high safety and low adverse effects profiles. This review will provide the reader with the foundational basic and clinical science linking the endocannabinoid system and the phytocannabinoids with their potentially therapeutic role in the management of chronic pain.”(The Endocannabinoid System, Cannabinoids, and Pain, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/) It is the terpenes in cannabis which modulate (modify or control) the effect that the cannabinoids within each sample will have on the user. This is why different strains of cannabis effect each user uniquely. For example, if you have 2 different types of cannabis and both have equal amounts of cannabinoids, but one gives you energetic effects and one gives you sedative effects, this is largely due to the different terpene profiles of the strains. Cannabinoids and terpenes have their own independent effects, but in combination they have been known to be vastly more effective than in isolation. The term “entourage effect” has become an easily identified piece of vocabulary in the cannabis community to describe the basic relationship between terpenes, cannabinoids, and other phytochemicals (chemicals made by plants) which are responsible for the vast therapeutic potential of cannabis. We at Heartland feel that the term “ensemble effect” better describes the individual importance that each cannabidiol and terpene brings to the effect. Instead of CBD acting as the most important single entity with everything else hanging on the edges, we see it as a conductor of the orchestra. Without CBD, each instrument (terpene) is trying to work on its own, but with CBD the sound changes from chaos to a beautiful piece of music. To explore that concept we will spotlight a terpene within each newsletter, including quotes of testing information from medical studies. We will also include the terpene profile of essential oils that have the particular terpene in them. IN THE SPOTLIGHT Spotlight Terpene: Beta-Caryophyllene Sources: Black Pepper, Copaiba Resin, Cloves, Hops, Oregano, Lavender, Rosemary Why this Terpene: Beta-Caryophyllene is important for several reasons but the primary reason is because of its size and molecular structure it has also been identified as a dietary cannabinoid. “Due to these properties, Beta-Caryophyllene is able to activate several receptors in the body, including CB2, which is usually activated most by CBD” (True Terpenes, 2019) Being able to activate the CB2 receptors within the endocannabinoid system similar to CBD lets this terpene enhance the benefits of CBD within the Gastrointestinal system, the Immune system and the Peripheral nervous system. “Although the CB(1) receptor is responsible for the psychomodulatory effects, activation of the CB(2) receptor is a potential therapeutic strategy for the treatment of inflammation, pain, atherosclerosis, and osteoporosis. Here, we report that the widespread plant volatile (E)-beta-caryophyllene [(E)-BCP] selectively binds to the CB(2) receptor (K(i) = 155 +/- 4 nM) and that it is a functional CB(2) agonist. Intriguingly, (E)-BCP is a common constituent of the essential oils of numerous spice and food plants and a major component in Cannabis.” (Gertsch et al., Beta-caryophyllene is a dietary cannabinoid, 2008 Jun 23, Epub) www.ncbi.nlm.nih.gov/pubmed/18574142 The terpenoid beta-caryophyllene has also been shown to inhibit the development of gastric lesions evoked in rats. As a possible protective agent within the gastric system many are using copaiba oil as an herbal remedy for stomach issues. However, like the majority of terpenes beta-caryophyllene has also proven to be a potent anti-inflammatory which is a primary source of chronic pain. This combination of natural benefits is slowly gaining ground as a homeopathic remedy for a multitude of issues. doTERRA a leader within the essential oil industry has this to say about this particular terpene: “Beta-caryophyllene is primarily known for its presence in the essential oils extracted from black pepper, clove, melissa, and rosemary, but the best source is the lesser-known oil copaiba. GC-MS assessments have shown that many sources of copaiba essential oil are composed of more than 50% beta-caryophyllene, and not surprisingly, the properties of this oil extracted from the oleoresin of Copaifera species trees is becoming a popular topic of research. There have been over 70 peer-reviewed studies published in scientific journals in the last handful of years evaluating the benefits of copaiba, several of which focus on its CB2-binding properties and the associated health benefits.” (Rodriguez D., Beta-Caryophyllene: Squashing the Essential Oil Debate with Science, harcourthealth.com) In conclusion our high levels of this particular terpene could be a contributing factor regarding our particular blends of CBD Hemp oil within our tinctures and topical products.
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    Meeting with Doctor for CIO and COS. Business will remain open and processing as usual.
  6. Pay By Phone - Primary Payment Method Pay with Credit Card by Phone Call Phone Number: +1-727-312-3121 Place your order, submit it, and then proceed with the on screen instructions to place your call and complete your order. It's just like ordering a pizza, except in this case it's really good for you and it can be mailed or delivered ❤️ . Nothing to sign up for No middle-man bank Fast Easy Secure
  7. Heartland CBD™ - Publishing Opportunity for Guest Posters and Guest Bloggers Your posts are important, and because you are providing value with your well written content, we are able to provide you with value, by offering the opportunity to have your article or post featured in our International Associates of Business Scholars peer reviewed journal. Your posts are always reviewed before being approved for the public, and our staff may or may not make adjustments to your content to ensure that it meets quality standards. Reply's to topics at this time are not currently considered for publication. EBSCO ISSN 2572-6706 (Print) ISSN 2572-6714 (Online) ---------- If your post has been chosen for publication you will be contacted by private message (also e-mail) to submit your authorization for IABS to publish your content in it's twice yearly release. This is perfect for authors and content writers to have for their resume, and perfect for students too! -------------- To qualify for publication, you only need to do the following: Create your account for Heartland CBD Create a topic Topic must relate to economics, business, marketing, strategy, or provide some sort of business insight or knowledge that can be learned from Topic must be well written and organized If your content is selected for publication, you will then be contacted and provided with further instruction. Happy posting!
  8. Welcome to the Public Community The community message boards are a powerful way for us all to stay connected, learn more about one another and our industry, and a way for us to provide a stronger point of communication from ourselves to the public, preserving company transparency. We value our customers and our guests very highly, and encourage you all to engage in discussions regarding the hemp and cannabis industry. From laws and regulations all the way to experiences and ways to improve our company. Heartland CBD invites you to sign up, whether you are a customer, a CBD user, an industry insider, or someone who has never even heard more than the acronym "CBD". We want to open discussions with everyone and provide everyone with an opportunity to speak freely without social media outlets clouding your view of us, nor our view of you. Tools You Have Available To You & What They Do - Community Message Boards Forums This place is called a forum, this "post" your reading is the starting post of what is called a "Topic" or "Thread" Topics / Threads This "topic" is called "Heartland CBD™ - A Guide to Using Our Forums" You can create your own topics when you are a registered member Posts This first post is considered the topic post. This is what the entire discussion of the "topic" will be centered around. The next post is simply a post, or a reply to a topic. You can quote posts of specific and multiple users to help organize your discussion or clarify to what you are responding too. You have a text editor similar to Word. It's easy to use, and you can use it to organize or highlight points of your post. Private Messages As a member you have a private message inbox here. Think of this as the forum's personal and private "email" system. Private messages are a great way to communicate privately with staff members Private messages are a great way to communicate with another member if you feel that what you are wanting to say to them is best left in private, outside of the topic. You can have a private message discussion between yourself and up to 5 people. Signatures Your profile has what is called a "signature" field. This is displayed at the bottom of every post and private message. The signature spot is ideal for Displaying your name or business Graphic art is allowed (400 w x 200 h in pixels) No nudity, profanity, drugs, violence, racism, hate, bigotry, or what may be considered offensive to the public. Keep your art PG Keep your signature free of redirect links Keep your signature something appropriate. If you were to walk into a public space, and you wanted to present yourself every time someone looked at you, your signature is your outfit. Wear your best. Avatars The picture that is on the side of every post is called an Avatar. You may upload a picture of your own and display an avatar. Avatars must be PG No nudity, profanity, drugs, violence, racism, hate, bigotry, or what may be considered offensive to the public. Referral System ($$$) When you refer a friend with your personal referral URL (located in your profile), anyone who signs up with your link and makes a purchase, will earn you a 10% commission, just for sharing Heartland CBD with your friends, family, neighbors, or co-workers. Commission is 10% of the entire order value. For example, if TOM refers his friend SIDNEY to Heartland CBD with his unique referral URL, and SIDNEY creates her account and makes a purchase at the value of $100.00 and the payment is processed and completed, TOM will receive +$10.00 credited to his Heartland CBD™ account. TOM can purchase products with the $10.00 he acquired from SALLY's referral commission as applied credit, otherwise TOM can request a payout to his PayPal™ account. ______________________ You may post here to test, ask questions about the community, and more. The more you ask, the more I will add to the guide! It helps us all to help each other! I look forward to meeting all of you!
  9. Philip Blair, MD, Col. (ret.), U.S. Army P&T® • April 2019 • Vol. 44 No. 4 Hemp-derived cannabidiol, used with concurrent standard treatments or alone, may be highly effective for alleviating posttraumatic stress disorder (PTSD), according to an open-label pilot study among combat veterans. The greatest improvements, said Dr. Philip Blair, whose interest in PTSD arose from his experience as a combat physician during the Gulf War, were in reductions of repeated disturbing memories, thoughts, and feelings associated with a stressful military environment. Common PTSD symptoms include avoidance, negative moods, re-experience, and anxiety. Prolonged activation of the stress responses can produce physical symptoms that compromise the body’s internal stability, resulting in physical dysregulations, decreased immune function, and chronic illness. Veterans with mental health issues also have an increased risk of suicide. Meeting Highlights: Integrative Healthcare Symposium Current standard PTSD treatments include antidepressants, anti anxiety agents, behavioral therapy, and sleep aid medications. Beyond recurring memories, many patients have chronic pain, opioid dependence, and musculoskeletal disorders that lead to additional drugs and therapies, Dr. Blair said. He pointed out that although marijuana relieves the painful thoughts of PTSD, it does not seem to help recovery. Furthermore, for many people, the tetrahydrocannabinol (THC) component of marijuana has disabling effects including lethargy, drowsiness, and memory impairment. The very low THC levels in cannabidiol derived from industrial hemp (= 3%) make it non-psychoactive with respect to these adverse effects. On the other hand, cannabidiol has been shown to modulate fear memory, emotional reconsolidation, memory processing, and the hypothalamic–pituitary–adrenal axis of hormone production (see Figure 1). Also, cannabidiol appears to rebalance the endocannabinoid system by acting on endocannabinoid receptors CB1R and CB2R, and by inhibiting fatty acid amide hydrolase, the enzyme responsible for degrading endocannabinoids.1 In an interview at his poster, Dr. Blair emphasized that cannabidiol seems to inhibit the reconsolidation pathways behind repeating memories and open up the extinction pathway that allows one to forget these same memories. The 30 study participants (aged 24–70 years), all veterans with PTSD diagnosed by the Veteran’s Administration, had continuing and chronically persisting symptoms. Lack of active medical management, however, was not an exclusion criterion. None of the participants had suicidal ideation nor a history of suicide attempts. Subjects completed the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) along with a brief clinical history. No changes in medications or therapies were recommended, and they were encouraged to continue their course of therapy. Each participant received liposomal cannabidiol in liquid form and was instructed to take 5 mg sublingually twice daily, and then to adjust the dose as needed to control PTSD symptoms. Subjects repeated the PCL-5 checklist at weeks 2 and 4, and were asked to keep a daily log using the PCL-5 numerical values. The average self-dose of cannabidiol was 15 mg/day. After two weeks, at mid-study, the average PCL-5 total score among 22 respondents was 57, down from the pre-cannabidiol treatment average score of 66. After four weeks of treatment, the average total score dropped to 41, with the most severe score down to 72 from an initial 100, and the lowest score down to 27 from 55. The average symptom score decreased by 67%. At the pre-treatment evaluation, 50% of participants had rated themselves as being “extremely” affected by repeated memories/thoughts/feelings. After treatment, no subjects rated such symptoms as affecting them “extremely” and only 28% said they were affected “quite a bit.” Pre-treatment, none of the participants selected “not at all,” whereas post-cannabidiol treatment, 28% of them selected “not at all.” With the permission of their primary medical providers, several participants discontinued using other prescription medications (including antidepressants and antianxiety drugs) during the course of the trial and have not restarted since its conclusion. Cannabidiol was well tolerated by all veterans, with no significant adverse events, hospitalizations, suicide attempts, or known emergency treatments. Dr. Blair also commented that, in some veterans, the rapid symptom decreases on first dose may indicate a specific endocannabinoid deficiency that is highly responsive to cannabidiol and that could be identified immediately in a clinical setting. He concluded that these preliminary results support a specific role for cannabidiol from industrial hemp for modulating PTSD physiology and indicate an “imperative need for more research.” REFERENCES 1. Lee JLC, Bertoglio LJ, Guimarães FS, Stevenson CW. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders [published online March 9, 2017]. Br J Pharmacol 2017; 174(19):3242–3256. doi: 10.1111/bph.13724
  10. Veteran CBD Discount Program by Heartland CBD™ How to Sign Up for your Veteran Discount Welcome to Heartland CBD™ ! If you are United States Military Active Service, or United States Military Veteran, you are qualified to get the exclusive pricing for your very much appreciated service for our nation. Materials & Information you will need: Your full name Your home address Your phone number A Digital Photocopy (or picture) of your Drivers License or Military Identification How to verify your veteran status with Heartland CBD: Go to https://veterancbd.us/verify/ Fill out the form as completely as you can (no sign up codes have been distributed at this time) Provide the picture of your Drivers License (baring the V) or your Military Identification Card. Submit the form What happens after I submit my verification application? Heartland CBD™ is a veteran owned company and has a system that safely identifies and protects the identities of United States Military. The review process generally takes anywhere from 1 - 5 business days depending on volume. Once we have verified your identity and confirmed your veteran status, you will receive an e-mail detaling your log-in information, including a generated password. I received my login information, now what? Now that you've received your log in details, you will want to sign in to your account and begin reviewing your new prices simply by shopping. All of your prices are automatically discounted.
  11. Hi-Tec Solar & Construction Heartland CBD and Hi-Tec Solar have entered an agreement on 04/19/2019 for homeowner residents in the state of Florida to receive 1 Year of Free CBD delivered to your door for going solar with Hi-Tec Solar. Rules of the Promotion You must be a homeowner You must qualify for solar energy for your household or business (**Business Owners MUST own the property they operate in to qualify**) You must successfully complete your solar installation with Hi-Tec Solar & Construction How you can ensure you get this promotion Hi-Tec Solar Canvassers will be in neighborhoods throughout Florida promoting this opportunity. They will ask you if you are interested, and you may tell them then. When in your free energy assessment appointment with Hi-Tec Solar & Construction, they will provide optional promotional deals, including this one. You may choose it then. You may request your free solar energy assessment appointment through Heartland CBD, and you will be kept as a Solar Energy member. Available Package Deals for CBD Delivery Once you've successfully qualified and placed your choice for Heartland CBD, you have your choice of the following packages. (Pet blend 200 is a 2 year, or x2 for 1 year). 1 Year of Original 500 1 Year of Appetite Suppressant 500 1 Year of Pet Blend 500 1 Year of Moisturizing Lotion x2 1 Year of Body Butter (Salve) 500 2 Years of Pet Blend 200
  12. CBD and Drug Interactions What can I do to be safe with CBD and Drugs? Talk to your doctor regularly. Keep track of everything (Blood sugars, Calories, Activities) Get blood tests regularly if you are on opiates and blood thinners Practice healthy habits, such as yoga and eating healthy foods If you can’t take it with Grapefruit, Don’t test it with CBD either. It is important to understand that everyone is chemically different, and that there is no solution that suits all individuals the same. What can be said, is that we all have an endocannabinoid system and it is important to explore it as an option of providing pharmacological effects through means of dietary consumption and use, much like spinach has iron, and grapefruit has compounds that interact with the body in complex ways, where mixing medication with certain foods is not the wisest idea. Heartland Hemp Inc. does not claim to be medical professionals, we do not claim to treat, diagnose, cure, relieve, or otherwise heal any sickness, illness, disease, ailment, or otherwise a medically definable condition. We encourage healthy choices, education, research, and well being. Methods of Delivery for Drugs and Cannabinoids When CBD was first coming out, it was previously believed that CBD had no real interactions with prescription drugs, however, this is not the case. This article addresses how CBD and other cannabinoids interact with the drug delivery system in the human body through what is known as the Cytochrome P450 Enzymes First, we must review the methods of delivery, which are the ways humans and animals are using CBD, or Cannabidiol. There are many ways to take CBD , lets first go over the methods of delivery. Inhalation by Smoking or Vaporization One of the most associated methods of taking medicinal marijuana is through smoking or vaporization or “vaping” cannabis extracts and cannabinoids extracted from cannabis or hemp. This method is currently being researched for it’s effects on the lungs with respiratory issues. Oral The oral method of delivery is the most common in prescription and over the counter (OTC) drugs. While this method is highly popular due to the ease of compliance from consumers, it lacks benefits in realms such as bioavailablity, meaning it can be time consuming or in some cases, difficult to fully introduce a drug or chemical into the body through this method. Oro-mucosal or Sublingual Taking pills, oils, and drugs that are sublingual have a higher bioavailability than most methods of consumption. This is because the tissues in the mouth are highly vascular, meaning that there are multiple pathways into the blood vessels through this method of drug consumption. Many CBD companies will recommend sublingual ingestion of their oils to improve bioavailability. Topical or Rectal Suppositories When looking to move into taking hemp CBD, it is important to understand that when ingesting CBD orally, there are some risks involved with about 60% of prescription drugs. Work closely with your doctor if you are on blood thinners or opiates. Another guideline is: If you cannot eat grapefruit with your prescription pill or OTC, don’t mix CBD with it either. Cytochrome P450 Enzymes THC (Tetrahydrocannabinol) and CBD (Cannabidiol) are metabolized by CYP3A4 and CYP2C9 CYP3A4 Inhibitors slightly increase the THC levels. CYP3A4 Inducers slightly decrease the THC levels. Tetrahydracannabinol (THC) is a CYP1A Inducer Theoretically, THC can decrease serum concentrations of: Clozapine Duloxetine Naproxen Cyclobenzaprine Olanzapine Haloperidol Chlorpromazine Cannabidiol (CBD) can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times. Steroids HMG CoA Reductase Inhibitors Calcium channel blockers Antihistamines Antibiotics Anesthetics Antipsychotics Antidepressants Anti-Epileptics Beta blockers PPIs NSAIDs Angiotension II blockers Oral hypoglcemic agents Sulfonylureas Other Drug Interactions According to the named studies, these interactions ocurred with use of THC, CBD, and sometimes fulls spectrum. It is important to note that these are not the ONLY studied effects or affected items. Wharfarin THC and CBD increase warfarin levels (Yamaori et al 2012). Frequent cannabis use has been associated with increased INR. Alcohol Alcohol may increase THC levels (Hartman 2015). Theophylline Smoked cannabis can decrease theophylline levels (Stout and Cimino 2014) Indinavir or nelfinavir Smoked cannabis had no effect (Abrams et al 2003). Docetaxel or irinotecan Cannabis infusion (tea) had no effect (Engels et al 2007). Clobazam In children treated with CBD for epilepsy, CBD increased clobazam levels (Geffrey et al 2015). Cannabinoids and Diabetes Cannabinoids such as CBD and THC have been undergoing studies for quite some time now, and while the complete evidence and methods of how cannabinoids interact with insulin in the body are few at this time, below are two quotes from reputable sources in regards to the studies going on with diabetes and cannabinoids. ~ Time – Healthland Taylor & Francis Online Toxicity and Lethality of Cannabinoids Serious adverse effects are rare with cannabis or its constituents. Marijuana has low to moderate dependence potential; the active dose is very far below the lethal dose. Active to Lethal Dose Ratio & Dependence Potential of Psychoactive Drugs Moving Forward with CBD Oils and Prescription Drugs Overall, the goal is to transition away from intoxicants that introduce a large variety of side effects, where hemp CBD oil is a promising regulator of the human body functions. The best way to take and use this information is to share this with your doctor and ask them about how you can get started with this holistic hemp and healthy habits lifestyle with the least risk to your health. Alternatively, if you are not interested in using CBD for it’s regulatory properties, you will find a safer method of delivery by means of using topical lotions that are infused with full spectrum cannabinoids. Citations https://www.projectcbd.org/science/cannabis-pharmacology/cbd-drug-interactions-role-cytochrome-p450 https://www.ncbi.nlm.nih.gov/pubmed/12126458 https://doh.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/Medical Cannabis Adverse Effects and Drug Interactions_0.pdf https://www.cbdschool.com/cbd-and-drug-interactions-an-easy-guide/ https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery https://en.wikipedia.org/wiki/Oral_mucosa https://en.wikipedia.org/wiki/Cytochrome_P450 http://healthland.time.com/2013/05/21/marijuana-the-next-diabetes-drug/ https://www.tandfonline.com/doi/full/10.1080/14787210.2018.1473764?scroll=top&needAccess=true https://heartlandhempinc.com/health/cbd-and-prescription-drugs/ <-- Original Article by Joseph Edwards at Heartland Hemp Inc.
  13. Heartland Hemp Inc.’s Definition of Ensemble Effect The Ensemble Effect describes when multiple components come together, such as an orchestra. When regarding Hemp and Cannabis the Ensemble Effect refers primarily to a full or broad spectrum of cannabinoids and phytocannabinoids are that equally important within the same proprietary mixture. First a spectrum including Cannabidiol (CBD) and Tetrahydrocannabinol (THC), while retaining as much of the CBG (Cannabigerol), CBN (Cannabinol), CBC(Cannabichromene), THCV (Tetrahydrocannabivarin), and many other currently unlisted phytocannabinoids that are obtained from the plants. The carrier oil involved should react and mix well with cannabinoids. Carriers such as hemp oil, coconut oil or sunflower oil to name a few are common and have their own benefits in delivery. The final piece to the ensemble effect includes the presence of terpenes (or terpenoids), which are currently still being closely studied, although many benefits have already begun to be associated with them. With these equally important components, and through a detailed and clean process, you create the ensemble effect in full. The Ensemble Effect ensures the most rapid delivery in the body when the most effective cannabinoids, phytocannabinoids, terpenoids, and oil mix together. This mixture allows each of their parts to perform their tasks at peak performance thanks to their ability to work harmoniously. Understanding Ensemble V.S Entourage Effect Heartland Hemp Inc. spent considerable time on reviewing these definitions, statements, and published medical studies in regards to theendocannabinoid system, the enzymatic process of metabolizing cannabinoids, and dictionary definitions in order to compare the definitions. Below we cover the history of the terminology, and provide supporting information. True Definitions of Ensemble and Entourage Ensemble: en·sem·ble [änˈsämbəl] NOUN a group of musicians, actors, or dancers who perform together.”a Bulgarian folk ensemble”synonyms: group · band · orchestra · combo · company · troupe · a scene or passage written for performance by a whole cast, choir, or group of instruments. the coordination between performers executing an ensemble passage.”a high level of tuning and ensemble is guaranteed” a group of items viewed as a whole rather than individually.”the buildings in the square present a charming provincial ensemble”synonyms: whole · whole thing · entity · unit · unity · body · piece · Entourage: en·tou·rage[ˌänto͝oˈräZH]NOUN a group of people attending or surrounding an important person.”an entourage of bodyguards”synonyms: retinue · escort · company · cortège · train · suite · court · staff · bodyguard· attendants · companions · followers · retainers · members of court · Dr. Lester Grinspoon Ensemble Effect as Defined by Dr. Lester Grinspoon It was in 2016 that Dr. Grinspoon interviewed with HighTimes Magazine where he told them that he preferred the term “Therapeutic Ensemble” which we too agree with. In his quote here, he goes on to say: In this situation, Dr. Grinspoon is referring to Cannabis. This is applicable to Hemp as well. For help with understanding the differences between Hemp and Cannabis, and also to see how Hemp and Cannabis are similar, read our article on The Differences Between Hemp and Cannabis. The Explanation of The Entourage Effect on CNN by Dr. Mechoulam & Dr. Sanjay Gupta This article discusses his published paper on the Entourage Effect. Dr. Sanjay Gupta The Entourage Effect As Written By Dr. Sanja Gupta Don’t be discouraged! This will be broken down and explained, no need for fancy words within lengthy paragraphs here! In the paper that Dr. Sanjay Gupta wrote, it’s first paragraph reads: While both descriptions hold an amount of viability too them, the Ensemble Effect is the best way to describe how the cannabinoids, phytocannabinoids, and terpenoids are reacting, acting, choreographing, and synchronizing to provide harmonious relief throughout the body. That is not to say that we disagree with Dr. Sanjay Gupta at all. Understanding The Effect Itself Through Dr. Gupta In this section of the article, you will be given the meaning of each section of the article, and then have that section of the article re-introduced to you with that explanation a little more fresh in your minds. Before we really dive in, it’s important we introduce Raphael Mechoulum. Who is Raphael Mechoulam? In his statements and in the CNN report, Raphael Mechoulum is referenced directly, as well as directly cited in the first paragraph of the Entourage Effectby Dr. Sanjay Gupta. Raphael Mechoulum Raphael Mechoulum is an important man in the cannabis and hemp industry thanks to his achievements , where his most notable achievement was in isolating Tetrahydrocannabinol Delta 9 (Activated THC). CBD, Cannabinoids, and Pharmacology Dr. Gupta continues immediately into his next points with discussing the “synergism” between “cannabidiol” or CBD and their pharmacological (pharmacy or pharmaceutical / medical) practices involving cannabis. What he is saying here in plain English: CBD works very well along side cannabis. He goes on to say: Other phytocannabinoids including THCV, CBG, and CBN also show promise in there medical applications. To read again with this explanation in mind: Terpenes or Terpenoids & Their Role Terpenes or terpenoids are the “smells” and “flavors” of the cannabis plants as well as other plants, however most interestingly, these smells and flavors are tell-tale signs of what the plant may be able to do for you. Dr. Gupta states that after many years of innovative plant breeding, different strains containing different phyto-therapeutic (natural plant therapy) properties, where such terpenes as Limonene (associated with gastrointestinal relief, anti-anxiety, and anti-depression) are being looked at in medical applications. Terpenes have also been designated as safe by the US Food Drug Administration, so possession and use of terpenes is perfectly fine. With this explanation, read it over again! Resources: https://hightimes.com/culture/the-ensemble-effect-not-the-entourage-effect-says-dr-grinspoon/ https://www.cnn.com/2014/03/11/health/gupta-marijuana-entourage/index.html https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2011.01238.x https://en.wikipedia.org/wiki/Raphael_Mechoulam https://en.wikipedia.org/wiki/Sanjay_Gupta https://www.cnn.com/profiles/sanjay-gupta-profile https://heartlandhempinc.com/science/ensemble-effect/ <-- Original Article by Joseph Edwards at Heartland Hemp Inc.
  14. In Canines, as well as any other species with a central nervous system, including dogs, cats, birds, lizards, etc. there is the Endogenous Cannabinoid or Endocannabinoid System, also referred to as the ECS. The most important notations are as follows: CB1 Receptors CB1 receptors are primarily located in the brain and central nervous system. This includes places such as Glial Cells (which are apart of the brain), Skin, Bones, and the Spleen. CB2 Receptors CB2 Receptors are generally located in peripheral organs, especially in immune cells. CB2 receptors are also found in the brain, but are also located in the Vascular System (the blood stream), the Lungs (breathing), Muscles (muscle control/memory), Gastrointestinal Track (digestive system), and the reproductive organs. Basics: Dog Endocannabinoid System The Endogenous Cannabinoid System in Canines / Dog Endocannabinoid System is only slightly different than what a human has, in terms of where the receptors are located, where the biggest differences come in at size and digestive system, and this is because of the structure of the dog muscularly and organically. CB1 receptors are in the brain primarily; This is the case with humans as well. CB2 receptors are located throughout the body from your head to your feet. The dog endocannabinoid system (ECS) is regulated much in the same way that humans regulate their own cannabinoid systems, where there is a difference is weight and the line between dose and overdose differs. There are also some medicinal differences if the dog is on any prescription medication. How much CBD do I give my pet? Weight Guide. Disclaimer Heartland Hemp Inc. provides this information based on spanned in-house research. All information is to be regarded as non-professional -non-medical suggestions based on common findings. These are not to be interpreted as medical fact. Monitor your pets while introducing any new substance or foods into their bodies. Full Spectrum Hemp CBD oils will not get your pet high, stoned, cause euphoria, or intoxicate your pet. Pet Medications Warning If your pet is on medication such as an opiate, a blood thinner, or any heart medication, only proceed with the assistance of your veterinarian, as CBD inhibits certain receptors and alters interactions that over 60% of medications use for a non-toxic entry into the body, where the introduction of CBD holds the potential to introduce toxic amounts of a drug into the system, due to CBD acting as a body functionality regulatorIf your pet is on medication such as an opiate, a blood thinner, or any heart medication, only proceed with the assistance of your veterinarian, as CBD inhibits certain receptors and alters interactions that over 60% of medications use for a non-toxic entry into the body, where the introduction of CBD holds the potential to introduce toxic amounts of a drug into the system, due to CBD acting as a body functionality regulator 5 – 10 lbs Pets weighing: 5 lb (2.26796 kg) – 10 lb (4.53592) 1mg – 5mg of Cannabidiol (CBD) in Full Spectrum = 1 serving. 11- 20 lbs Pets weighing: 11 lb (4.98952) – 20 lb (9.07185) 2mg – 10mg of Cannabidiol (CBD) in Full Spectrum = 1 serving. 21- 30 lbs Pets weighing: 21 lb (9.52544) – 30 lb (13.6078) 3mg – 15mg of Cannabidiol (CBD) in Full Spectrum = 1 serving. Over 30lb Pets weighing: 21 lb (9.52544) – 30 lb (13.6078) 4mg – 20mg of Cannabidiol (CBD) in Full Spectrum = 1 serving. There is no currently designated toxicity point for introducing CBD into pets, however it does not mean that it is impossible to do so. This is a very new field of study, so be sure to check back for updates when looking to use CBD for your pet. Dogs, CBD, and Medication Tips What Dog Owners Are Using CBD For: Pet owners are turning to cannabidiol, particularly full spectrum cannabidiol CBD hemp and cannabis derived oils that contain large ranges of cannabinoids including CBD, CBN, CBC, CBG, etc. to assist their dogs with the following major issues (see disclaimer above). Anxiety Epilepsy Arthritis Cancer Asthma Dizzyness Hip Displacia Lethargic Behavior Anger Issues Hyperactivity Heat Rashes Cuts and Wounds Irritable Bowel Syndrom (IBS) Nausea Discomfort Basic Guide To Introducing CBD to your Dog: Dogs with serious conditions and needs: Determine the appropriate CBD mg (milligram) for your dog. Severe: 500+mg Not Severe: 250mg – 300mg Start with 1 dose (3/4 of a dropper[3/4 of 1 ml] or less if a smaller dog and not so severe [ 5 drops – 1/2 of 1 ml dropper] ) Dog may want water after first dose to wash down the oil. Most dogs love the taste. Dogs with rashes and skin conditions: Determine the appropriate CBD mg (milligram) for your dog. Severe: 500+ Not Severe: 250mg – 300mg Apply 1 (one) ml of oil to the affected area and massage gently in. (You may mix this into a lotion or cream for your dog) Measure the effect. Try not to allow the dog to lick the area to which the full spectrum oil was placed until it is in the skin. This way the most is gotten out of the oil being placed topically onto the dogs skin. How to tell if the CBD is helping your dog: When administering full spectrum hemp cbd oils to your pet, please anywhere from 30 – 60 minutes before adjusting the dose. The Oil is Working: Dog is calm and relaxed Dog is focused Dog is not nauseous or dizzy Dog is able to move comfortably Dog is able to rest comfortably Dog is energetic and playful Dog displays reduced symptoms or symptoms are no longer present The Oil is NOT Working: No change in behavior No change in symptoms displayed Lethargic Dizzy & Nauseous Not able to eat / Vomits food Rashes go no where or increase in severity Dog is not responsive to the cannabinoids whatsoever What to do when the oil is not working: Change method of delivery. Move from oral to topical, switch it up, or do both at the same time. Increase dose slowly or as you and/or your vet see fit. Monitor your dog closely. Love your dog, pet them, and tell them it’s going to be okay, they need your support. Observe and create options for you and your dog to explore. Heartland Hemp Inc. does not give medical advice, is not a licensed physician, veterinarian, or health practitioner of any kind. Heartland Hemp Inc. shares this information solely for educational purposes. Consult a trusted veterinarian with questions you may have. Blood Thinners: Any dogs on medication for the intended purpose to thin blood should be monitored closely when introducing CBD or Full Spectrum Hemp CBD Oil. What happens to blood thinners with CBD and Full Spectrum Hemp Oil? Cannabidiol, especially when full spectrum is known to boost and improve regulatory systems and with additional blood flow regulation, the blood thinner will ultimately be more effective. While introducing CBD into the dog is safe, do so 1 drop at a time, per dose, and measure the effects. It is helpful to have a veterinarian monitor the effects with the appropriate equipment. What happens when you mix dog medications with CBD or Full Spectrum Oils that contain THC? Because this area of study is so new, it is ultimately difficult to say how the dog will react to the introduction of cannabinoids while still on medication, however, it is safe to say that we have seen medications be discontinued and replaced with CBD without any noticeable (when we say noticeable, we mean visually and to the best of our intellectual capabilities of observation, with the need of studies and case studies to be released and reported on) negative side effects. Puppies and CBD Hemp Oil Small puppies, small dogs, or basically one of the cutest little best friends full of love fur and adorableness you could ask for, can be in need of assistance. It is hard to think that small animals may need help with their health, but just the same as humans, dogs with birth defects, diseases, and deficiencies are all too common, and CBD is becoming a popular option for many families. So when do you make the decision that your small puppy could possibly benefit from the introduction of CBD oils? If you find that you are needing to make purchases on pills, medications, treatments, etc. for your puppy at an early age outside of vaccinations and regular check ups, you may want to consider introducing cannabinoids into your puppies diet. So how do you do this safely? It can be tricky to be sure, because puppies are delicate creatures that will be more sensitive. Introducing CBD to a puppy is easy, start with 1 drop mixed into their 8oz water bowl in the morning, and measure the effects. Do not exceed 1 drop unless you see no difference in behavior. Only increase 1 drop at a time. Diluting the CBD oil is important, because a small dog has a much smaller pathway that needs to be traveled, overwhelm the puppies endocannabinoid system, and you will likely have to deal with some diarrhea and a very sleepy dog. Outside of the sleepiness and laxative effects, it remains uncertain as to what will happen when going above and beyond the typical maximum extent of 1 serving of 0.5mg of CBD for a small dog that does not have any severe health issues. The human digestive system is much more complex than that of a dogs. This illustated anatomy of this dog shows the overall look at how the dog works internally. Introducing CBD Orally The most effective way for anyone to take CBD is orally, unless the relief you are seeking will come from something like a lotion, cream, shampoo, or conditioner that is infused with CBD and Hemp. When ingested orally, given as a food, drink, or straight as the oil (recommended), the dog will be able to digest the liquids and allow quick distribution of the cannabinoids throughout the dogs body. Once the oil is inside, the enzymes that control the distribution of cannabinoids in the dogs body will react and distribute the cannabinoids CBD, CBN, CBC, CBG, THC, and others evenly thoughout the dogs body. In the picture you see a bad looking rash with spots and clear irritation and inflammation to the skin, and is likely even warm or hot to the touch. Introducing CBD Topically Using oils that are able to be applied topically can be one of the best ways to deal with skin rashes on dog skin and fur. Apply the CBD onto the afflicted area where the rash is, and spread it as evenly and thoroughly as possible. Try your best not to allow your dog to lick or nip at the area that the oil is applied too, as you want the most possible saturation of the oil into the skin. It is suggested that you start with 1 milliliter of oil and apply it either directly onto the skin, or with a recommended and vet approved lotion or cream.
  15. Endocannabinoid / Endogenous Cannabinoid System Introduction Why is it called the Endocannabinoid System? Endocannabinoid System or ECS – What is it, and why do we call it by this name? Endocannabinoid improper noun; – (indo-can-nah-bih-noy-d ) : Endocannabinoids and their receptors can be found throughout body of any species that has a central nervous system, naturally. CB1 receptors are in the brain, and CB2 receptors are in peripheral organs such as arms, legs, and especially within the gastrointestinal (gas-troh-in-test-in-all) region (stomach). The system that controls the distribution of these is called the Endocannabinoid System (ECS). It goes without saying that Cannabis and cannabinoids are synonymous. The fact is, that the endocannabinoid system was named after the very plant that helped with its discovery within the body: Cannabis. Discovering the Endocannabinoid System Discovered in the 20th century in 1992 by Raphael Mechoulam, our Endocannabinoid or Endogenous Cannabinoid System ( ECS ) consists of numerous cannabinoid receptors that are naturally occurring in the mammalian brain, and play a pivotal role in physiological processes such as mood, memory, pain, and appetite. The two main ECS receptors CB1 and CB2, can be found within the brain and as you are moving throughout the bodies’ nervous system the receptors appear in the peripheral organs and tissues within the entire body. Notice From The Author This Article was written by: Joseph Edwards on June 6th, 2018 @ 7:35 PM – This article was not written to provide medical advice, perform medical diagnosis, nor for the sake of assisting with a “cure” or “treatment” of any kind. This article is written to provide information on detailed research for the Endogenous Cannabinoid System. All sources are cited. The endocannabinoid system regulates the body by taking in the various cannabinoids, including THC and CBN. The receptors however have a profile that needs to fit in order for them to be activated or stimulated. In the image above: You will notice that there are CB1 and CB2 receptors that are lined up with CBN and THC. CBD does not have a receptor lined up with it in the graphic. CBD by itself does not directly fit into CB1 or CB2 receptors without extensive saturation (consumption of CBD in larger doses over longer time) before it will begin to stimulate and interact with the CB1 and CB2 receptors. Ensemble Effect: The ensemble effect (also referred to as the entourage effect) is the reason that full spectrum hemp extracts are growing in popularity. The full range of cannabinoids such as CBN, THC, CBG, CBA, THCV, etc. assisting the CBD, where the presence of more cannabinoids both in variety and miligram, will increase the potency and efficiency that much more. Fastest Way To Get CBD Benefits When more than 3 cannabinoids are introduced into the system, where CBD and THC are both included, you get the basic openings to the ensemble effect, which allows faster saturation of the CB1 and CB2 receptors and quicker reaction to the CBD. Introduction to Receptors CB1 Receptors Brain / CNS / Spinal Cord Cortigal Regions Cerebelum Brainstem Basal Ganglia Olfactory Bulb Thalamus Hypothalamus Thyroid Upper Airways Liver Adrenals Ovaries Prostate Testes CB2 Receptors Eye (CB1 & CB2) Stomach Heart (CB1 & CB2) Pancreas (CB1 & CB2) Digestive Tract (CB1 & CB2) Bone (CB1 and CB2) Non-CB1 and non-CB2 receptors are located in cells of the blood vessels: Epithelial cells of arterial blood vesels (Non-CB1 and non-CB2). CB2 receptors are located in the cells of the Lymphatic and Immune System Spleen Thymus Tonsis Blood lmphocytes Understanding How The Endocannabinoid System Works The endogenous cannabinoid system is a major part of the human bodies regulatory systems, for things such as eye sight, digestion, the nervous system, our heart, and so much more. Essentially the Endocannabinoid System is existent in the body in most if not all vertebrates. Dustin Sulak, DO In short, the above is saying that the Endocannabinoid system is responsible for the preservation, elongation, and improvement of the human body andpromote quality of life, even for those who at one point believed that they would surely die from their terminal disease. Let’s look at how this all comes together. Stimulating The Endocannabinoid System You might be asking yourself, why would I want to stimulate my endocannabinoid system? What’s the purpose? As it turns out, medical studies being published regularly in regards to the endocannabinoid system are all involved with stimulating it and using it to treat certain human ailments. Here is an example using peppers and the capsaicin oils derived from them. When stimulating our various CB1 and CB2 receptors, as well as TRPV1 and TRPV2 receptors, with cannabinoids, we experience various side effects based on the cannabinoids and terpenes consumed, and the experience will vary or even differ greatly, based on what is called the method of delivery. The method of delivery entails the way in which one consumes cannabinoids and terpenes, which may include: Oral (Eating / Drinking) Topical Application (Skin cream, lotions, etc.) Vaporizing (Extracts, eLiquids, vape pens, etc.) Smoking Stimulation of the various receptors is most effectively possible through digesting certain foods and oils that contain known stimulants. Citations for Resources Discussed in The Endocannabnoid Guide by Heartland Hemp Inc. http://norml.org/library/item/introduction-to-the-endocannabinoid-system https://www.leafscience.com/2017/03/17/the-endocannabinoid-system-a-beginners-guide/ https://en.wikipedia.org/wiki/Endocannabinoid_system https://www.erowid.org/plants/cannabis/cannabis_pharmacology2.shtml https://en.wikipedia.org/wiki/Cannabinoid https://draxe.com/capsaicin/ https://www.webmd.com/pain-management/what-is-capsaicin https://www.ncbi.nlm.nih.gov/books/NBK5260/ https://www.sciencedirect.com/topics/neuroscience/trpv1 http://www.mdpi.com/2218-1989/7/4/55 http://www.mdpi.com/1422-0067/19/3/833/htm http://mechoulamthescientist.com/ https://heartlandhempinc.com/health/endocannabinoid-system/ <-- Original Article by Joseph Edwards on Heartland Hemp Inc.
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